Lionel Messi goes up against Paulo Dybala at the Camp Nou in the main match of the week.
Messi will try to get Barcelona first spot in the group as his team has been struggling lately. With qualification secured for both teams, Dybala will try to get the win for Juventus after a slight run of poor form lately.
Lautaro Martinez could be playing in the Europa League or even not playing at all in Europe for the rest of the season. Currently in last place in the group, Inter are up against Shakhtar and qualification is far from secured.
Manchester City and FC Porto are both through to the next round in the group while Ajax and Atalanta play in what would determine second place in the group. A draw would be enough for Atalanta while Ajax will need the win.
Lucas Ocampos and Marcos Acuña with Franco Vázquez are into the next round of the Champions League while Joaquín Correa and Gonzalo Escalante could still finish first in their group.
The Argentine trio of Leandro Paredes, Mauro Icardi and Ángel Di María are tied in second place along with Manchester United and RB Leipzig, all with 9 points.
Here are the matches for this week:
Zenit vs. Borussia Dortmund
Lazio (Joaquín Correa, Gonzalo Escalante) vs. Club Brugge
FC Barcelona (Lionel Messi) vs. Juventus (Paulo Dybala)
Chelsea (Willy Caballero) vs. FC Krasnodar
RB Leipzig vs. Manchester United (Marcos Rojo, Sergio Romero)
Dynamo Kyiv vs. Ferencváros
PSG (Leandro Paredes, Mauro Icardi, Ángel Di María) vs. Istanbul Başakşehir F.K.
Stade Rennais vs. Sevilla (Lucas Ocampos, Marcos Acuña, Franco Vázquez)
FC Midtjylland vs. Liverpool
Ajax (Lisandro Martínez, Nicolás Tagliafico) vs. Atalanta (José Luis Palomino, Alejandro Gómez, Cristian Romero)
Bayern Munich vs. Lokomotiv Moscow
Real Madrid vs. Borussia Monchengladbach
RB Salzburg vs. Atletico Madrid (Ángel Correa)
Manchester City (Sergio Agüero) vs. Olympique de Marseille (Leonardo Balerdi, Darío Benedetto)
Inter Milan (Lautaro Martínez) vs. Shakhtar Donetsk
Olympiacos (Maximiliano Lovera) vs. FC Porto (Agustín Marchesín)